Indicators on phenobarbital sodium obat apa You Should Know
Indicators on phenobarbital sodium obat apa You Should Know
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pentobarbital will minimize the level or effect of naloxegol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Usage of naloxegol with strong CYP3A4 inducers is not proposed
Observe Carefully (2)pentobarbital will minimize the extent or effect of buprenorphine, extensive-acting injection by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Intently. Sufferers who transfer to buprenorphine long-performing injection from transmucosal buprenorphine coadministered with CYP3A4 inducers ought to be monitored to be certain buprenorphine plasma degrees are satisfactory.
Contraindicated (1)pentobarbital will reduce the extent or effect of lumacaftor/ivacaftor by impacting hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will minimize the level or effect of prednisone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
Phenytoin, sodium valproate, valproic acid: The effect of barbiturates around the metabolism of phenytoin seems for being variable. Some investigators report an accelerating effect, although others report no effect. Because the effect of barbiturates on the metabolism of phenytoin is not predictable, phenytoin and barbiturate blood amounts ought to be monitored a lot more routinely if these drugs are given concurrently.
pentobarbital will lessen the level or effect of pantoprazole by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Mysterious.
pentobarbital increases toxicity of ifosfamide by influencing hepatic/intestinal enzyme CYP3A4 metabolism. read more Use Warning/Keep an eye on. CYP3A4 inducers might improve the metabolism of ifosfamide to its active alkylating metabolites.
Contraindicated (1)pentobarbital will lessen the level or effect of fostemsavir by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will decrease the extent or effect of voriconazole by affecting hepatic enzyme CYP2C9/ten metabolism. Small/Importance Unfamiliar.
fentanyl intranasal and pentobarbital equally improve sedation. Stay clear of or Use Alternate Drug. Restrict use to patients for whom alternative remedy solutions are insufficient
Keep track of Closely (1)pentobarbital will decrease the extent or effect of tadalafil by influencing hepatic/intestinal enzyme CYP3A4 metabolism.
fentanyl intranasal and pentobarbital each improve sedation. Stay clear of or Use Alternate Drug. Limit use to sufferers for whom alternative treatment possibilities are inadequate
On the other hand, using barbiturates as sedatives in the postoperative surgical period of time and as adjuncts to cancer chemotherapy is nicely founded.
pentobarbital will reduce the extent or effect of eucalyptus by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Unidentified.